Posted on February 8, 2024October 24, 2025 by sadhana

Oxycodone Acetaminophen Percocet, Tylox, and others: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

This drug comes with risks if you don’t take it as prescribed. The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with opioid agonists. Because the duration of reversal is expected to be less than the duration of action of oxycodone in OXYCONTIN, carefully monitor the patient until spontaneous respiration is reliably reestablished. OXYCONTIN will continue to release oxycodone and add to the oxycodone load for 24 to 48 hours or longer following ingestion, necessitating prolonged monitoring.

Drug Interaction Studies

There is a relationship between increasing oxycodone plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. In opioid-tolerant patients, the situation may be altered by the development of tolerance to opioid-related adverse reactions see DOSAGE AND ADMINISTRATION. Pregnant rats were treated with 0.5, 2, 4, and 8 mg/kg oxycodone hydrochloride (0.08, 0.3, oxycodone uses side effects precautions 0.7, and 1.3 times the human daily dose of 60 mg/day, respectively based on a mg/m2 basis) during the period of organogenesis. Oxycodone did not cause adverse effects to the fetus at exposures up to 1.3 times the human dose of 60 mg/day. The high dose produced maternal toxicity characterized by excessive gnawing on forelimbs and decreased body weight gain.

Monitor for respiratory depression, especially during initiation of OXYCONTIN or following a dose increase. Instruct patients to swallow OXYCONTIN tablets whole; crushing, chewing, or dissolving OXYCONTIN tablets can cause rapid release and absorption of a potentially fatal dose of oxycodone see WARNINGS AND PRECAUTIONS. If you are taking the oxycodone extended-release tablets, swallow them whole; do not chew, break, divide, crush, or dissolve them.as you may receive too much oxycodone at once instead of slowly over 12 hours.

Oxycodone/acetaminophen works to change how your body feels and responds to pain. Oxycodone works by binding to and activating specific receptors in your body, causing pain relief. Oxycodone/acetaminophen is a combination medicine that is commonly used to treat severe pain. Despite these measures, oxycodone remains a vital tool for pain management when used responsibly. Once oxycodone enters the bloodstream, it crosses the blood-brain barrier and binds to mu-opioid receptors. These receptors are part of the central nervous system and regulate pain and reward pathways.

Females And Males Of Reproductive Potential

However, there were insufficient numbers of patients less than 11 years of age enrolled in this study to establish the safety of the product in this age group.
When opioid analgesics are being discontinued due to a suspected substance use disorder, evaluate and treat the patient, or refer for evaluation and treatment of the substance use disorder.
Too few patients less than 11 years were enrolled in the clinical trial to provide meaningful safety data in this age group.
There are no well-controlled clinical studies evaluating the safety and efficacy with dosing more frequently than every 12 hours.
Your doctor may have you mix the concentrate with a small amount of liquid or food.

People who are addicted to drugs might want to steal this medicine. It is very important that your doctor check your progress while you are using this medicine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Contraindications for Oxycontin

Pregnant rabbits were treated with 1, 5, 25, and 125 mg/kg oxycodone hydrochloride (0.3, 2, 8, and 40 times the human daily dose of 60 mg/day, respectively, based on a mg/m2 basis) during the period of organogenesis. Oxycodone did not cause adverse effects to the fetus at exposures up to 40 times the human dose of 60 mg/day. The 25 mg/kg and 125 mg/kg doses high doses produced maternal toxicity characterized by decreased food consumption and body weight gain. OXYCONTIN contains oxycodone, a Schedule II controlled substance. As an opioid, OXYCONTIN exposes users to the risks of addiction, abuse, and misuse. Because extended-release products such as OXYCONTIN deliver the opioid over an extended period of time, there is a greater risk for overdose and death due to the larger amount of oxycodone present see Drug Abuse And Dependence.

Interaction with other medications, history of opioid addiction, and underlying medical conditions must be examined thoroughly.
OXYCONTIN in healthy subjects in pharmacokinetic studies, steady-state levels were achieved within hours.
Generic drugs usually cost less than the brand-name version.
Narcan (4 mg/spray) and ReVive (3 mg/spray) are brand names available OTC.

What should I know about storage and disposal of this medication?

Ask your health care provider about keeping naloxone available, as this can be used to reverse the effects of oxycodone. Get emergency help if you have any of the following symptoms. Opioid-Induced Hyperalgesia (OIH) occurs when an opioid analgesic paradoxically causes an increase in pain, or an increase in sensitivity to pain.

Overdose Information for Oxycontin

Taking cut, broken, chewed, crushed, or dissolved OXYCONTIN enhances drug release and increases the risk of overdose and death. If a CYP3A4 inhibitor is discontinued, consider increasing the OXYCONTIN dosage until stable drug effects are achieved. If concomitant use is necessary, consider dosage reduction of OXYCONTIN until stable drug effects are achieved. Evaluate patients at frequent intervals for respiratory depression and sedation. The concomitant use of OXYCONTIN and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of OXYCONTIN and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of OXYCONTIN is achieved see WARNINGS AND PRECAUTIONS.

What should I tell my care team before I take this medication?

Oxycodone/acetaminophen should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

The following dosing information is for use only in pediatric patients 11 years and older already receiving and tolerating opioids for at least five consecutive days. For the two days immediately preceding dosing with OXYCONTIN, patients must be taking a minimum of 20 mg per day of oxycodone or its equivalent. OXYCONTIN is not appropriate for use in pediatric patients requiring less than a 20 mg total daily dose.

It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. Using too much of this medicine may cause infertility (unable to have children).

Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants

In patients with circulatory shock, OXYCONTIN may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of OXYCONTIN in patients with circulatory shock. OXYCONTIN may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock see OVERDOSE. Serious, life-threatening, or fatal respiratory depression may occur with the use of OXYCONTIN.